John Pascal Lab @LabPascal
Structural cell biology of DNA repair and ADP-ribose signaling pascal-lab-udem.org Université de Montréal Joined May 2021-
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Followers212
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Following88
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John Pascal Lab retweeted
Online Now: PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) dlvr.it/TG7yqg
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John Pascal Lab retweeted
TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects! Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…
John Pascal Lab retweeted
I’m extremely proud to share that my first first author paper was published today. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP academic.oup.com/nar/article/do…
Our latest paper on PARP2 is now out! Thanks to @zha_lab for a very nice collaboration. Clinical PARP inhibitors allosterically induce PARP2 retention on DNA science.org/doi/10.1126/sc…
John Pascal Lab retweeted
New dropbox has been set up at the University of Montreal @UMontreal in Montréal, QC! Pickups are Fridays at 2pm, located in Room 2057, Pavillon J.-Armand-Bombardier. Thanks to John M. Pascal for hosting this new box! 🥳🥳🥳
John Pascal Lab retweeted
Check our latest work on PARP2 and PARP inhibitors. Great collaboration with @zha_lab! Clinical PARP inhibitors allosterically induce PARP2 retention on DNA biorxiv.org/content/10.110…
John Pascal Lab retweeted
We have a position open for a postdoctoral scientist. The projects in the lab focus on structural biology of ADP-ribosylation and drug discovery. #parp #fbmm #structuralbiology rekry.saima.fi/certiahome/ope…
John Pascal Lab retweeted
Does distinct end of poly(ADP-ribose) matter? @LabPascal and our lab @DasovichMorgan @IsabelRUribe @SJCHENG1 found antiviral PARP13 binding to 2' end of PAR in an unexpected way. Excited to see our technology to label both PAR ends come to good use! cell.com/cell-reports/f…
We are excited to share our latest structural study on PARP1 mechanism of activation! Cheers to @IcrLordLab for a nice collaboration! AddThis | Home authors.elsevier.com/a/1fMUZ3vVUPK8…
@MichaelNADbio Thanks Michael, Susan and Andreas for a organizing a wonderful conference! It was great to see everybody!
Happy to share our first Cryo-EM structure! Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase cell.com/structure/full…
Our new paper on PARP1/2 and HPF1 is out @Naturecommunications! HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications disq.us/t/42yjt6d
Check out our latest story on HPF1 regulation of PARP1/2!
HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADPribose modifications biorxiv.org/cgi/content/sh… #bioRxiv
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