Science Translational Medicine @ScienceTM
Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine. science.org/journal/stm Washington, DC Joined February 2011-
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A small molecule therapy for #Alzheimers disease that activates #TREM2 in #microglia boosts the breakdown of amyloid-beta in neurons and mice and is well-tolerated in healthy individuals and patients, according to results from a phase 1 trial. @sanofi scim.ag/4jYmDEv
A new Editorial stresses the importance of the simple but fundamental concept of prevention in combating antimicrobial resistance, and calls for more support for IPC and WASH in low- and middle-income countries to reduce antibiotic demand. @EdinUniUsher scim.ag/3Uv4kfY
With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite's lifespan. scim.ag/4yvGu2q
Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @moderna_tx scim.ag/47Vt445
By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896 scim.ag/4zzZLzU
The new issue of #ScienceTranslationalMedicine is out! A large clinical study in China uncovers "clocks" of human aging that may predict chronic disease, a new mRNA antibody therapy could better tackle ever-evolving SARS-CoV-2 variants, and more. scim.ag/4yjVa3G
Moran Amit is the 2026 recipient of the #AAAS Martin and Rose Wachtel Cancer Research Award for his research on how cancer reprograms peripheral nerves to evade immunity—and how to target this relationship to support #immunotherapy. @UTMDAnderson scim.ag/4yGqnPL
Gut bacteria such as Lactobacillus prime intestinal epithelial cells in newborn mice to produce the antimicrobial protein calprotectin, making them less susceptible to sepsis and infection-related death. @CincyChildrens scim.ag/3WexRLg
A topical combo of the mite-killing compound #flavesone and the ovicidal drug #abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. @QIMRB_Institute @DeepsDarshi scim.ag/4z4XLPJ
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic #TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial. scim.ag/3Tthp9c
An artificial lymph node provides a protected haven for tolerogenic dendritic cell therapy for autoimmune encephalitis in mice, with possible implications for #MultipleSclerosis therapy. scim.ag/4yDX28t
Don't miss this afternoon's prize-winning lecture from Moran Amit, winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award. Sign up now to attend his talk in person at the @aaas building or via livestream: scim.ag/4701AKi
🎉 Congratulations to Moran Amit, winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award! Sign up now for his lecture about his prize-winning work on how cancers reprogram nerves, which is 9 October at the @aaas building and via livestream: scim.ag/4701AKi
With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite’s lifespan. scim.ag/4yvGu2q
The new issue of Science Translational Medicine has arrived! This week features an essay from the winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award, a new drug candidate for schistosomiasis, and more. scim.ag/4zdt3nD
A digitized arm motor recovery scale can assess movement profiles in #stroke survivors wearing wrist-worn accelerometers in real-world settings, and yields improvements in sensitivity that may streamline future trials. @ivanlee_umass @manningcics scim.ag/4jAYvHR
How does #MRSA persist in the kidneys? New preclinical work identifies the renal inner medulla as a reservoir for the bacteria, which co-opt tissue polyamines for growth in a hyperosmotic environment that impedes neutrophil migration. @IUKidney scim.ag/4juytWH
Advanced imaging and genetics identify features of the spleen associated with #coronary artery disease risk, as well as genetic variants associated with these splenic CAD features. @MassGenBrigham @pnatarajanmd scim.ag/4yuQYP6
A topical combo of the mite-killing compound #flavesone and the ovicidal drug #abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. @QIMRB_Institute @DeepsDarshi scim.ag/4z4XLPJ
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Nature Medicine @NatureMedicine
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Nature Biomedical Eng... @natBME
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